Microsatellite instability and loss of heterozygosity in human pterygia
نویسندگان
چکیده
منابع مشابه
Loss of heterozygosity and microsatellite instability as predictive markers among Iranian esophageal cancer patients
Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. Our aim in this study was to illustrate microsatellite DNA alteration in esophageal cancer. Materials and Methods: DNA was extracted from formalin fixed paraffin embedde...
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Microsatellite instability (MSI) has been described in colorectal and other cancers. The purpose of this study was to determine the presence of MSI in breast cancer and to correlate its occurrence with clinicopathological parameters. For microsatellite markers we examined mono-, di-, tri-, and tetranucleotide repeats that, due to their polymorphic nature, may also be used to investigate loss of...
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Genetic alterations, such as loss of heterozygosity (LOH) or microsatellite instability (MI), have been reported in both malignant and benign disorders. In order to identify loci of deoxyribonucleic acid (DNA) mutation in asthma, MI and LOH were studied in sputum cells. DNA was extracted from cells in the sputum and blood cells of 22 patients with moderate asthma. Cells were analysed for MI and...
متن کاملEvaluation of loss of heterozygosity and microsatellite instability in human pterygium: clinical correlations.
AIMS To evaluate the incidence of loss of heterozygosity (LOH) and microsatellite instability (MI) in pterygia and their possible correlation with clinical variables. METHODS 50 pterygia, blood, and conjunctival specimens were obtained. A personal and family history was recorded for each patient. Amplification of 15 microsatellite markers at regions 17p, 17q, 13q, 9p, and 9q was performed usi...
متن کاملLoss of heterozygosity and microsatellite instability on chromosome 2q in human oral squamous cell carcinoma.
Allelic imbalance or loss of heterozygosity (LOH) and microsatellite instability (MSI) have been used to identify regions on chromosomes that may contain putative tumor suppressor genes. To obtain a detailed understanding of genetic alterations in oral cancer, 10 highly polymorphic markers mapped on chromosome 2 were used to examine 25 cases of oral squamous cell carcinoma (SCC). With these, we...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1997
ISSN: 0007-1161
DOI: 10.1136/bjo.81.6.493